MCBO / Publications
Tuzlak S, Haschka MD, Mokina AM, Rülicke T, Cory S, Labi V, Villunger A
Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis
FEBS J. 2018 Mar 2. doi: 10.1111/febs.14426. [Epub ahead of print] PubMed PMID: 29498802.

Haschka M, Karbon G, Fava LL, Villunger A
Perturbing mitosis for anti-cancer therapy: is cell death the only answer?
EMBO Rep. 2018 Mar;19(3). pii: e45440. doi: 10.15252/embr.201745440. Epub 2018 Feb 19. Review. PubMe

Tan GC, Negro G, Pinggera A, Tizen Laim NMS, Mohamed Rose I, Ceral J, Ryska A, Chin LK, Kamaruddin NA, Mohd Mokhtar N, A Jamal AR, Sukor N, Solar M, Striessnig J, Brown MJ, Azizan EA

Hypertension (Dallas, Tex.: 1979), 5. Juni 2017

Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4. PubMed PMID: 29044097; PubMed Ce

Vogel G, Janecke A, Krainer I, Gutleben K, Witting B, Mitton S, Mansour S, Ballauff A, Roland J, Engevik A, Cutz E, Müller T, Goldenring J, Huber L, Hess M
Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with Microvillus Inclusion Disease
Traffic. 2017 Apr 13. doi: 10.1111/tra.12486. [Epub ahead of print]

Rabachini T, Fernandez-Marrero Y, Montani M, Loforese G, Sladky V, He Z, Bachmann D, Wicki S, Villunger A, Stroka D, Kaufmann T
BOK promotes chemical-induced hepatocarcinogenesis in mice
Cell Death Differ. 2017 Dec 11. doi: 10.1038/s41418-017-0008-0. [Epub ahead of print] PubMed PMID: 2

Schenk R, Tuzlak S, Carrington E, Zhan Y, Heinzel S, Teh C, Gray D, Tai L, Lew A, Villunger A, Strasser A, Herold M
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment
Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.

Schuler F, Weiss JG, Lindner SE, Lohmüller M, Herzog S, Spiegl SF, Menke P, Geley S, Labi V, Villunger A
Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis
Nat Commun. 2017 Nov 22;8(1):1697. doi: 10.1038/s41467-017-01850-4. PubMed PMID: 29167438; PubMed Ce

Janecke A, Xu R, Steichen-Gersdorf E, Waldegger S, Entenmann A, Giner T, Krainer I, Huber L, Hess M, Frishberg Y, Barash H, Tzur S, Schreyer-Shafir N, Sukenik-Halevy R, Zehavi T, Raas-Rothschild A, Mao C, Müller T
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications
Hum Mutat. 2017 Apr;38(4):365-372. doi: 10.1002/humu.23192. Epub 2017 Mar 6.

Culig Z, Puhr M
Interleukin-6 and prostate cancer: Current developments and unsolved questions
Mol Cell Endocrinol. 2017 Mar 16. pii: S0303-7207(17)30181-8. doi: 10.1016/j.mce.2017.03.012. [Epub

Mastrolia V, Flucher S, Obermair G, Drach M, Hofer H, Renström E, Schwartz A, Striessnig J, Flucher B, Tuluc P
Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
Diabetes. 2017 Jan 23. pii: db151349. doi: 10.2337/db16-0336. [Epub ahead of print]

Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J
Lower Affinity of Isradipine for L-Type Ca(2+) Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson’s Disease
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 37, Nr. 28 (12. Ju

Monteleone S, Lieb A, Pinggera A, Negro G, Fuchs JE, Hofer F, Striessnig J, Tuluc P, Liedl KR
Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains
Biophysical Journal 113, Nr. 7 (3. Oktober 2017): 1485–95

Pinggera, A, Mackenroth L, Rump A, Schallner J, Beleggia F, Wollnik B, Striessnig J
New Gain-of-Function Mutation Shows CACNA1D as Recurrently Mutated Gene in Autism Spectrum Disorders and Epilepsy
Human Molecular Genetics, 4. Mai 2017

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, Hackl H, Trajanoski Z
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Cell Rep. 2017 Jan 3;18(1):248-262. doi: 10.1016/j.celrep.2016.12.019.

Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A
Signalling strength determines proapoptotic functions of STING
Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w. PubMed PMID: 28874664; PubMed Cent

Campiglio M, Flucher B
STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads
Sci Rep. 2017 Jan 23;7:41003. doi: 10.1038/srep41003.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf C, Pope L, Rossen N, Flucher B, DeGrado W, Minor DL Jr.
Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci. 2017 Mar 17. doi: 10.1021/acschemneuro.6b00454. [Epub ahead of print]

Tuzlak S, Schenk R, Vasanthakumar A, Preston S, Haschka M, Zotos D, Kallies A, Strasser A, Villunger A, Herold M
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection
Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.

Lindner SE, Lohmüller M, Kotkamp B, Schuler F, Knust Z, Villunger A, Herzog S
The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells
EMBO Rep. 2017 Sep;18(9):1604-1617. doi: 10.15252/embr.201643735. Epub 2017 Jul 13. PubMed PMID: 287

Fava L, Schuler F, Sladky V, Haschka M, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg E, Villunger A
The PIDDosome activates p53 in response to supernumerary centrosomes
Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.

Pichler R, Fritz J, Heidegger I, Steiner E, Culig Z, Klocker H, Fuchs D
The predictive and prognostic role of serum neopterin and tryptophan breakdown in prostate cancer.
Cancer Sci. 2017 Jan 20. doi: 10.1111/cas.13171. [Epub ahead of print]

Sladky V, Schuler F, Fava LL, Villunger A
The resurrection of the PIDDosome - emerging roles in the DNA-damage response and centrosome surveillance
J Cell Sci. 2017 Nov 15;130(22):3779-3787. doi: 10.1242/jcs.203448. Review. PubMed PMID: 29142064.

Rzhepetskyy Y, Lazniewska J, Proft J, Campiglio M, Flucher B, Weiss N
A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane
Channels (Austin). 2016 Sep 2;10(5):346-354. Epub 2016 May 5

Boltengagen M, Huang A, Boltengagen A, Trixl L, Lindner H, Kremser L, Offterdinger M, Lusser A
A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
Nucleic Acids Res. 2016 Mar 18;44(5):2145-59.

Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.
Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007. Epub 2016 Mar 15.

Pinggera A, Striessnig J
Cav 1.3 (CACNA1D) L-type Ca2+ channel dysfunction in CNS disorders.
J Physiol. 2016 Feb 4. doi: 10.1113/JP270672.

Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, Hechenberger C, Hackl H, Kessler R, Willi M, Gstir R, Krogsdam A, Lusser A, Poewe W, Wenning G, Hüttenhofer A, Stefanova N
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications
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Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Sci Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930. PubMed PMID: 26868434; PubMed Central PMCID: P

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. PubMed PMID: 26450454; PubMed C

Pfeiffenberger E, Sigl R, Geley S
Conditional RNAi Using the Lentiviral GLTR System.
Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10.

Höfer J, Akbor M, Handle F, Ofer P, Puhr M, Parson W, Culig Z, Klocker H, Heidegger I
Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide.
Oncotarget. 2016 Sep 13;7(37):59781-59794. doi: 10.18632/oncotarget.10926.

Willi M, Yoo KH, Wang C, Trajanoski Z, Hennighausen L.
Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation
Nucleic Acids Res. 2016 Dec 1;44(21):10277-10291.

Alonso Y Adell M, Migliano S, Teis D
ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission
FEBS J. 2016 Sep;283(18):3288-302. doi: 10.1111/febs.13688. Review.

Curwin A, Brouwers N, Alonso Y Adell M, Teis D, Turacchio G, Parashuraman S, Ronchi P, Malhotra V
ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
Elife. 2016 Apr 26;5. pii: e16299. doi: 10.7554/eLife.16299.

Flucher B, Tuluc P
How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?
J Physiol. 2016 Nov 29. doi: 10.1113/JP273423. [Epub ahead of print]

Sebald J, Willi M, Schoberleitner I, Krogsdam A, Orth-Höller D, Trajanoski Z, Lusser A
Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster
PLoS One. 2016 Apr 19;11(4):e0153476. doi: 10.1371/journal.pone.0153476. eCollection 2016.

Tuzlak S, Kaufmann T, Villunger A
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.
Genes Dev. 2016 Oct 1;30(19):2133-2151. Review. PubMed PMID: 27798841; PubMed Central PMCID: PMC5088

Pichler R, Gruenbacher G, Culig Z, Brunner A, Fuchs D, Fritz J, Gander H, Rahm A, Thurnher M
Intratumoral Th2 predisposition combines with an increased Th1 functional phenotype in clinical response to intravesical BCG in bladder cancer.
Cancer Immunol Immunother. 2016 Dec 22. doi: 10.1007/s00262-016-1945-z. [Epub ahead of print]

Sakamoto K, Wehde B, Yoo K, Kim T, Rajbhandari N, Shin H, Triplett A, Rädler P, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner K
Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling
Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. PubMed PMID: 27044867; PubMed

Benedetti B, Benedetti A, Flucher B
Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice
Eur J Neurosci. 2016 Jun;43(11):1486-98. doi: 10.1111/ejn.13241. Epub 2016 Apr 18

Knackmuss U, Lindner S, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ. 2016 Feb;23(2):242-52.

Sochalska M, Schuler F, Weiss J, Prchal-Murphy M, Sexl V, Villunger A
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis
Oncogene. 2016 Oct 3. doi: 10.1038/onc.2016.362. [Epub ahead of print] PubMed PMID: 27694901

Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J
Novel insights into the PKCβ-dependent regulation of the oxidoreductase p66Shc.
J Biol Chem. 2016 Sep 13. pii: jbc.M116.752766. [Epub ahead of print] PubMed PMID: 27624939.

Siegmund K, Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.

Pfeifhofer-Obermair C, Albrecht-Schgör K, Peer S, Nairz M, Siegmund K, Klepsch-Pedit V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Cell Commun Signal. 2016 Jul 28;14(1):14

Handle F, Erb H, Luef B, Höfer J, Dietrich D, Parson W, Kristiansen G, Santer F, Culig Z
SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells.
Mol Cancer Res. 2016 Jun;14(6):574-85. doi: 10.1158/1541-7786.MCR-15-0495. Epub 2016 Apr 6.

Stanika R, Campiglio M, Pinggera A, Lee A, Striessnig J, Flucher B, Obermair G
Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology
Sci Rep. 2016 Oct 6;6:34528. doi: 10.1038/srep34528

Luef B, Handle F, Kharaishvili G, Hager M, Rainer J, Janetschek G, Hruby S, Englberger C, Bouchal J, Santer F, Culig Z
The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1.
Endocr Relat Cancer. 2016 Jun;23(6):495-508. doi: 10.1530/ERC-16-0160. Epub 2016 Jun 2.

Schrötter K, Dayal A, Grabner M
The mammalian skeletal muscle DHPR has larger Ca2+ conductance and is phylogenetically ancient to the early ray-finned fish sterlet (Acipenser ruthenus).
Cell Calcium. 2016 Oct 23. pii: S0143-4160(16)30163-4. doi: 10.1016/j.ceca.2016.10.002. [Epub ahead

Naschberger A, Fürnrohr B, Lenac Rovis T, Malic S, Scheffzek K, Dieplinger H, Rupp B
The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling
Acta Crystallogr D Struct Biol. 2016 Dec 1;72(Pt 12):1267-1280.

Dunzendorfer-Matt T, Mercado E, Maly K, McCormick F, Scheffzek K
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113.

Lammirato A, Patsch K, Feiereisen F, Maly K, Nofziger C, Paulmichl M, Hackl H, Trajanoski Z, Valovka T, Huber L, Vietor I
TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation
BMC Biol. 2016 Oct 25;14(1):95.

Pichler R, Fritz J, Zavadil C, Schäfer G, Culig Z, Brunner A
Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer.
Oncotarget. 2016 Jun 28;7(26):39916-39930. doi: 10.18632/oncotarget.9537.

Tuluc P, Benedetti B, Costé de Bagneaux P, Grabner M, Flucher B
Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.
J Gen Physiol. 2016 Jun;147(6):437-49.