Ottina Eleonora Marisa Rosa, M.Sc.

University / Clinic: Medical University Innsbruck
Institute: Division of Developmental Immunology
Research Area: Cell death signaling


Career followup:
  Eleonora Ottina spent six months (April 12-October 12) at the Walter and Eliza Hall Institut of Medical Research in Melbourne, Australia.

Research Topic:
Elucidation of the physiological role of the Bcl-2 pro-survival homologue A1

Oral Presentation Award at the EMBO Molecular Medicine Workshop 2011

ECDO Scholarships and oral presentation at the 19th Euroconference on Apoptosis “Metabolism, Epigenetics and Cell Death”

Selected publications:
  Ottina E, Peperzak V, Schoeler K, Carrington E, Sgonc R, Pellegrini M, Preston S, Herold MJ, Strasser A, Villunger A
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice
Nat Commun. 2017 Oct 18;8(1):1028. doi: 10.1038/s41467-017-01022-4. PubMed PMID: 29044097; PubMed Ce

  Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. PubMed PMID: 26450454; PubMed C

  Ottina E, Sochalska M, Sgonc R, Villunger A
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell Death Dis. 2015 Jan 22;6:e1611.

  Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson G
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
J Immunol. 2015 Feb 1;194(3):1316-22.

  Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W
Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol. 2014 Jun;95(6):853-66.

  Ottina E, Pellegrini M, Villunger A
Guarding effector T-cell survival: all for one, Mcl-1 for all?
Cell Death Differ. 2013 Aug;20(8):969-71.

  Ottina E, Tischner D, Herold M, Villunger A
A1/Bfl-1 in leukocyte development and cell death
Experimental Cell Research (2012), doi: 10.1016/j.yexcr.2012.01.021

  Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt H, Villunger A, Herold M
Targeting anti-apoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood. 2012 Jun 21;119(25):6032-42.

  Grespi F , Ottina E, Yannoutsos N, Geley S, Villunger A
Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.
PLoS ONE 6(3): e18051. doi:10.1371/journal.pone.0018051

  Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the proapoptotic BH3-only protein Noxa
Cell Death Differ. 2011 Jun 10.

  Tischner D, Wöss C, Ottina E, Villunger A
Bcl2-regulated cell death signalling in the prevention of autoimmunity.
Cell Death and Disease 1, e48; doi:10.1038/cddis.2010.27

  Casiraghi M, Bazzocchi C, Mortarino M, Ottina E, Genchi C
A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris).
Vet Parasitol. 2006 Nov 5;141(3-4):368-72. Epub 2006 Jul 20.