Dayal Anamika, PhD

University / Clinic:
Institute: Dept of Medical Genetics, Clinical and Molecular Pharmacology Division of Biochemical Pharmacology
Research Area: Skeletal-muscle excitation-contraction (EC) coupling


Research Topic:
Structural-functional relationship of the Ca2+ channel β1a subunit

Studying structural-functional relationship of the CaV1.1 Ca2+ channel β1a subunit in skeletal muscle excitation-contraction coupling by expressing different β isoforms and chimeras in β1a-null (relaxed) zebrafish embryos (in-vivo) and in dissociated muscle cells (in-vitro).

Selected publications:
  Schrötter K, Dayal A, Grabner M
The mammalian skeletal muscle DHPR has larger Ca2+ conductance and is phylogenetically ancient to the early ray-finned fish sterlet (Acipenser ruthenus).
Cell Calcium. 2016 Oct 23. pii: S0143-4160(16)30163-4. doi: 10.1016/j.ceca.2016.10.002. [Epub ahead

  Dayal A, Bhat V, Franzini-Armstrong C, Grabner M
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle.
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7488-93

  Dayal A, Schredelseker J, Franzini-Armstrong C, Grabner M
Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPR β1a subunit
Cell Calcium. 2010 Jun;47(6):500-6. Epub 2010 May 6

  Schredelseker J, Shrivastav M, Dayal A, Grabner M
Non-Ca2+-conducting Ca2+ channels in fish skeletal muscle excitation-contraction coupling.
Proc Natl Acad Sci U S A. 107(12): 5658-63

  Grabner M, Dayal A
Crosstalk via the Sarcoplasmic Gap: The DHPR-RyR Interaction.
Curr Top Membr. 2010;66:115-38.

  Schredelseker J, Dayal A, Schwerte T, Franzini-Armstrong C, Grabner M.
Proper restoration of excitation-contraction coupling in the dihydropyridine receptor β1-null zebrafish relaxed is an exclusive function of the β1a subunit
J Biol Chem. 2009 Jan 9;284(2):1242-51. Epub 2008 Nov 13.