Hinterleitner Reinhard, DI (FH)

University / Clinic: Medical University Innsbruck
Institute: Dept. for Medical Genetics, Clinical and Molecular Pharmacology
 
Research Area: T-cell signalling, Immunology

Email: reinhard.hinterleitner@i-med.ac.at
Web: www.sfb021.at/baier/


Research Topic:


Selected publications:
 
  Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang C, Viola A, Pfeifhofer-Obermair C, Baier G
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
J Mol Cell Biol. 2013 Jun 26

  Meisel M, Hermann-Kleiter N, Hinterleitner R, Gruber T, Wachowicz K, Pfeifhofer-Obermair C, Fresser F, Leitges M, Soldani C, Viola A, Kaminski S, Baier G
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
Immunity. 2013 Jan 24;38(1):41-52; Epub 2013 Jan 3.

  Gruber T, Hinterleitner R, Pfeifhofer-Obermair C, Wolf D, Baier G
Engineering effective T-cell based antitumor immunity.
Oncoimmunology. 2013 Feb 1;2(2):e22893.

  Gruber T, Hinterleitner R, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger J, Loibner H, Lametschwandtner G, Wolf D, Baier G
Augmentation of tumor vaccine efficacy by combination with adoptive transfer of ex vivo synthetic siRNA cblb-silenced CD8+ T lymphocytes
PLOS ONE

  Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger J, Loibner H, Lametschwandtner G, Wolf D, Baier G
Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model.
PLoS One. 2012;7(9):e44295.

  Paolino M, Thien C, Gruber T, Hinterleitner R, Baier G, Langdon W, Penninger J
Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b-Regulated T Cell Functions.
J Immunol. 2011 Feb 15;186(4):2138-47. Epub 2011 Jan 19

  Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger J, Baier G
PKC-theta Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation.
Science Signal. 2009 Jun 23;2(76):ra30