Mairhofer David, M.Sc.

University / Clinic: Medical Universitiy IBK
Institute: Department of Dermatology
 
Research Area: Role of DC in skin cancer with a special emphasis on T cell responses against melanoma

Email: david.mairhofer@i-med.ac.at
Web: http://dermatologie.uki.at/page.cfm?vpath=forschung/laboratory-for-langerhans-cell-research#Staff

  Funded by: FWF

Research Topic:
Dendritic cells (DC) are antigen-presenting cells serving as a bridge between the innate and the adaptive immune system. Their main function is to process and present antigen on the cell surface to immune cells. There are numerous DC subsets in the skin and their mode of action is to survey the peripheral tissue for foreign antigen. However, DC are compromised in mounting an effective immune response to control tumor growth and the reason for this is largely unknown. In this project, we want to investigate the role of the various skin DC subsets in T cell responses against melanoma. Ultimately, our findings will be important for enhancing the efficacy of immunotherapeutical options for treating melanoma.

Selected publications:
 
  Mairhofer D, Ortner D, Tripp C, Schaffenrath S, Fleming V, Heger L, Komenda K, Reider D, Dudziak D, Chen S, Becker J, Flacher V, Stoitzner P
Impaired gp100-Specific CD8+ T Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
J Invest Dermatol. 2015 Jun 29.

  Flacher V, Tripp C, Mairhofer D, Steinman R, Stoitzner P, Idoyaga J, Romani N
Murine Langerin+dermal dendritic cells prime CD8+T cells while Langerhans cells induce cross-tolerance.
EMBO Mol Med. 2014 Aug 1;6(9):1191-204.

  Voisin B, Mairhofer D, Chen S, Stoitzner P, Mueller C, Flacher V
Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice.
Voisin BExp Dermatol. 2014 May;23(5):354-6.