Pasqualini Lorenza, MSc

University / Clinic: Innsbruck Medical University
Institute: Department of Urology
Research Area: Androgen receptor (AR) signaling in prostate cancer


  Funded by: FWF

Research Topic:
Lately, several miRNAs expression profiling studies have disclosed a specific miRNAs signature associated with prostate cancer (PCa) tissues as well as prostate cell lines indicating miRNAs as potential tumor suppressor genes or onocomiRs. Relying on this finding, we confirmed the existence of a relationship between AR and miRNAs in two AR positive prostate cancer cell lines, especially in terms of AR regulation of specific miRNAs and their host genes. Differential expression of the candidate miRNAs, miR-22 and miR-29a, was also validated in tissue specimens. Currently, we are identifying the potential down-stream targets of our miRNAs of interest to further understand their role in PCa. Карло Пазолини
Carlo Pazolini

Selected publications:
  Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno S, Schweiger M, Fuchsberger C, Klocker H
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.
Mol Endocrinol. 2015 Jul;29(7):1037-54.

  Bu H, Schweiger M, Manke T, Wunderlich A, Timmermann B, Kerick M, Pasqualini L, Shehu E, Fuchsberger C, Cato A, Klocker H
Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells
FEBS J. 2013 Mar;280(5):1249-66.