Ortner Nadine Jasmin,

University / Clinic: University of Innsbruck
Institute: Institute of Pharmacy, Department of Pharmacology and Toxicology
Research Area: Molecular pharmacology of voltage-gated calcium channels

Email: Nadine.Ortner@uibk.ac.at
Web: www.uibk.ac.at/pharmazie/pharmakologie/

Research Topic:
Voltage-gated Ca2+ channels open in response to membrane depolarization and mediate Ca2+ influx into excitable cells to trigger a variety of physiological processes, such as muscle contraction, release of neurotransmitters and hormones, gene expression and pacemaking in heart and neuronal cells. Mutations in the pore-forming alpha1 subunit of L-type Ca2+ channels (LTCCs) were found in patients suffering from various diseases, such as aldosterone-producing adenomas (Cav1.3), sinoatrial node dysfunction and deafness (SANDD) syndrome (Cav1.3), Timothy syndrome (Cav1.2) or congenital stationary night blindness type 2 (Cav1.4). Moreover, Cav1.3-mediated Ca2+ currents in dopaminergic substantia nigra pars compacta neurons are implicated to play a role in the pathophysiology of Parkinson’s disease. Our goal is to investigate the influence of disease-related LTCC mutations on gating and current properties of these channels and to evaluate the therapeutic potential of substances that can modulate the activity of LTCCs.

Selected publications:
  Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J
Lower Affinity of Isradipine for L-Type Ca(2+) Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson’s Disease
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 37, Nr. 28 (12. Ju

  Kaur G, Pinggera A, Ortner N, Lieb A, Sinnegger-Brauns M, Yarov-Yarovoy V, Obermair G, Flucher B, Striessnig J
A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-Gated Cav1.2 Calcium Channel Function.
J Biol Chem. 2015 Aug 21;290(34):21086-100.

  Ortner N, Striessnig J
L-type calcium channels as drug targets in CNS disorders.
Channels (Austin). 2016;10(1):7-13.

  Striessnig J, Ortner N, Pinggera A
Pharmacology of L-type calcium channels: novel drugs for old targets?
Curr Mol Pharmacol. 2015;8(2):110-22.

  Lieb A, Ortner N, Striessnig J
C-terminal modulatory domain controls coupling of voltage-sensing to pore opening in Cav1.3 L-type Ca(2+) channels.
Biophys J. 2014 Apr 1;106(7):1467-75.

  Ortner NJ, Bock G, Vandael DH, Mauersberger R, Draheim HJ, Gust R, Carbone E, Tuluc P, Striessnig J
Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.
Nature communications