Costé de Bagneaux Pierre,

University / Clinic: Medical University Innsbruck
Institute: Department of Physiology and Medical Physics
 
Research Area: Physiology, Cell Biology

Email: Pierre.Coste@i-med.ac.at
Web:  

  Funded by: FWF

Research Topic:
Calcium channels play a fundamental role in organism as they regulate essential functions like muscle contraction or synaptic transmission.
There are different type of calcium channels and they all share relatively similar sequences but their biophysical properties differ.
My project aims to study the molecular mechanism driving voltage sensitivity in L-type calcium channel, using site directed mutagenesis and electrophysiology.

Selected publications:
 
  Tuluc P, Benedetti B, Costé de Bagneaux P, Grabner M, Flucher B
Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.
J Gen Physiol. 2016 Jun;147(6):437-49.