Sprenger Simon,

University / Clinic:
Institute: Division Cell Biology, Biocenter, IMU
Research Area: Molecular Cell Biology

Email: s.sprenger@i-med.ac.at
Web: https://www.i-med.ac.at/cellbio/labore/Membrane_Traffic_and_Signaling/index.html

  Funded by: FWF

Research Topic:
The molecular mechanism of ESCRT mediated membrane remodeling:

The selective degradation of ubiquitinated membrane proteins via the multivesicular body pathway (MVB) to lysosomes plays a key role for cellular homeostasis. The ESCRT (endosomal sorting complexes required for transport) machinery is an important player in this pathway for recognition of ubiquitinated proteins and for forming intraluminal vesicles (ILVs) that bud away from the cytoplasm into the lumen of the multivesicular bodies.

How the ESCRT machinery remodels the membrane of the MVBs to form intraluminal vesicles, and how this is coordinated with cargo sorting is not understood. We hypothesize that the AAA- ATPase Vps4 induces conformational changes in ESCRT-III filaments to convert an initial membrane deformation complex into a membrane scission machine.

Selected publications: