Grespi Francesca, M.Sc.

University / Clinic: Innsbruck Medical University
Institute: Division of Developmental Immunology
Research Area: bcl-2 regulated cell death signaling


Research Topic:
Francescas PhD work describes for the first time the molecular basis for Bmf isoform generation and new biological functions for this BH3-only protein

MCBO Award 2008, 1st Poster Price @ the 17th Euroconference on Cell Death, Paris, 2009 Travel fellowship for Keystone Conference on Cell Death, Whistler, CDN, March 2009

Francesca is currently working at:
MRC Toxicology Unit
Hodgkin Building
PO Box 138
University of Leicester
Lancaster Road

Selected publications:
  Ottina E, Grespi F, Tischner D, Soratroi C, Geley S, Ploner A, Reichardt H, Villunger A, Herold M
Targeting anti-apoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice.
Blood. 2012 Jun 21;119(25):6032-42.

  Grespi F , Ottina E, Yannoutsos N, Geley S, Villunger A
Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis.
PLoS ONE 6(3): e18051. doi:10.1371/journal.pone.0018051

  Kirschnek S, Vier J, Gautam S, Frankenberg T, Rangelova S, Eitz-Ferrer P, Grespi F, Ottina E, Villunger A, Häcker H, Häcker G
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the proapoptotic BH3-only protein Noxa
Cell Death Differ. 2011 Jun 10.

  Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
Cell Death Differ. 2010 Nov;17(11):1672-83

  Frenzel A, Grespi F, Chmelewskij W, Villunger A
Bcl2 family proteins in carcinogenesis and the treatment of cancer
Apoptosis. 2009 Apr;14(4):584-96

  Labi V, Grespi F, Baumgartner F, Villunger A (2008)
Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
Cell Death Differ. 2008 Jun;15(6):977-87.