Bu Huajie, PhD

University / Clinic: Innsbruck Medical University
Institute: Department of Urology
Research Area: Regulation of Hag2 and Hag3 in prostate cancer by androgens

Email: Huajie.Bu@i-med.ac.at

Research Topic:
Using the androgen - regulated genes hAG2 and hAG3 as model genes the function of the androgen receptor as a transcription factor is investigated. Emphasis is on the identification of the regulatory elements in the gene promoters and on the involvement of accessory proteins (AR co-modulators) in the transcription complex. For that proteomics techniques are established in cooperation with the group of Lukas Huber for isolation and analysis of androgen receptor protein complexes (the "androsome").

Huajie is currently postdoctoral fellow in the Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Austria семена чиа
зеленый кофе

Selected publications:
  Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno S, Schweiger M, Fuchsberger C, Klocker H
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.
Mol Endocrinol. 2015 Jul;29(7):1037-54.

  Santer F, Erb H, Oh S, Handle F, Feiersinger G, Luef B, Bu H, Schäfer G, Ploner C, Egger M, Rane J, Maitland N, Klocker H, Eder I, Culig Z
Mechanistic rationale for Mcl1 inhibition during androgen deprivation therapy
Oncotarget. 2015 Mar 20;6(8):6105-22.

  Köhler A, Demir Ü, Kickstein E, Krauss S, Aigner J, Aranda-Orgillés B, Karagiannidis A, Achmüller C, Bu H, Wunderlich A, Schweiger M, Schäfer G, Schweiger S, Klocker H, Schneider R
A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling.
Mol Cancer. 2014 Jun 9;13:146.

  Bu H, Schweiger M, Manke T, Wunderlich A, Timmermann B, Kerick M, Pasqualini L, Shehu E, Fuchsberger C, Cato A, Klocker H
Anterior gradient 2 and 3--two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells
FEBS J. 2013 Mar;280(5):1249-66.

  Kong L, Schäfer G, Bu H, Zhang Y, Zhang Y, Klocker H
Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway.
Carcinogenesis. 33:751-9, 2012.

  Bu H, Bormann S, Schäfer G, Horninger W, Massoner P, Neeb A, Lakshmanan V, Maddalo D, Nestl A, Sültmann H, Cato A, Klocker H
The anterior gradient 2 (AGR2) gene is overexpresses in prostate cancer and is a urine sediment marker for prostate cancer detection.
Prostate. 2011 May;71(6):575-87. doi: 10.1002/pros.21273. Epub 2010 Oct 13

  Bu H, Rosdahl I, Sun X, Zhang H
Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients
J Cancer Res Clin Oncol. 2007 Nov;133(11):859-66. Epub 2007 May 11

  Bu H, Rosdahl I, Holmdahl-Kallen K, Sun X, Zhang H
Significance of glutathione S-transferases M1, T1 and P1 polymorphisms in Swedish melanoma patients
Oncol Rep. 2007 Apr;17(4):859-64