Puhr Martin, PhD

University / Clinic: Innsbruck Medical University
Institute: Department for Urology
Research Area: regulation and function of SOCS3 in prostate cancer

Email: martin.puhr@i-med.ac.at

Research Topic:
the main aim of this project is to understand the role and the function of SOCS3 (suppressor of cytokine signaling 3) in prostate cancer especially the regulation of this protein in response to growth factors, which are over expressed in prostate cancer patients

Martin is currently postdoctoral fellow in the Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Austria

Selected publications:
  Culig Z, Puhr M
Interleukin-6 and prostate cancer: Current developments and unsolved questions
Mol Cell Endocrinol. 2017 Mar 16. pii: S0303-7207(17)30181-8. doi: 10.1016/j.mce.2017.03.012. [Epub

  Höfer J, Akbor M, Handle F, Ofer P, Puhr M, Parson W, Culig Z, Klocker H, Heidegger I
Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide.
Oncotarget. 2016 Sep 13;7(37):59781-59794. doi: 10.18632/oncotarget.10926.

  Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno S, Schweiger M, Fuchsberger C, Klocker H
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.
Mol Endocrinol. 2015 Jul;29(7):1037-54.

  Höfer J, Kern J, Ofer P, Eder I, Schäfer G, Dietrich D, Kristiansen G, Geley S, Rainer J, Gunsilius E, Klocker H, Culig Z, Puhr M
SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.
Endocr Relat Cancer. 2014 Jan 30;

  Massoner P, Thomm T, Mack B, Untergasser G, Martowicz A, Bobowski K, Klocker H, Gires O, Puhr M
EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205.
Br J Cancer. 2014 Aug 26;111(5):955-64.

  Puhr M, Höfer J, Neuwirt H, Eder I, Kern J, Schäfer G, Geley S, Heidegger I, Klocker H, Culig Z
PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells.
Oncotarget. 2014 Dec 15;5(23):12043-56.

  Höfer J, Schäfer G, Klocker H, Erb H, Mills I, Hengst L, Puhr M, Culig Z
PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21.
Am J Pathol. 2012 May;180(5):2097-107. Epub 2012 Mar 23.

  Puhr M, Höfer J, Schäfer G, Erb H, Oh S, Klocker H, Heidegger I, Neuwirt H, Culig Z
Epithelial to Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and is Mediated by Reduced Expression of miR-200c and miR-205.
Am J Pathol. 2012 Oct 3. pii: S0002-9440(12)00653-0. doi: 10.1016/j.ajpath.2012.08.011

  Puhr M, Santer F, Neuwirt H, Marcias G, Hobisch A, Culig Z
SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling.
Endocr Relat Cancer. 2010 May 18;17(2):525-38. Print 2010 Jun.

  Gu L, Vogiatzi P, Puhr M, Dagvadorj A, Lutz J, Ryder A, Addya S, Fortina P, Cooper C, Leiby B, Dasgupta A, Hyslop T, Bubendorf L, Alanen K, Mirtti T, Nevalainen M
Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.
Endocr Relat Cancer. 2010 May 18;17(2):481-93. Print 2010 Jun.

  Neuwirt H, Puhr M, Cavarretta I, Mitterberger M, Hobisch A, Culig Z
[Androgens stimulate the expression of SOCS-3 and inhibits their effect on proliferation and secretion]
Aktuelle Urol. 2009 Aug;40(4):231-4. Epub 2009 Jul 24. German.

  Puhr M, Santer F, Neuwirt H, Susani M, Nemeth J, Hobisch A, Kenner L, Culig Z
Down-regulation of suppressor of cytokine signaling-3 causes prostate cancer cell death through activation of the extrinsic and intrinsic apoptosis pathways.
Cancer Res. 2009 Sep 15;69(18):7375-84. Epub 2009 Sep 8.

  Neuwirt H, Puhr M, Santer F, Susani M, Doppler W, Marcias G, Rauch V, Brugger M, Hobisch A, Kenner L, Culig Z
Suppressor of cytokine signaling (SOCS)-1 is expressed in human prostate cancer and exerts growth-inhibitory function through down-regulation of cyclins and cyclin-dependent kinases.
Am J Pathol. 2009 May;174(5):1921-30. Epub 2009 Mar 26.

  Neuwirt H, Arias M, Puhr M, Hobisch A, Culig Z
Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells.
Prostate 2008 Nov 1;68(15):1647-54.

  Neuwirt H, Puhr M, Cavarretta I, Mitterberger M, Hobisch A, Culig Z
Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion.
Endocr Relat Cancer. 2007 Dec;14(4):1007-19

  Bellezza I, Neuwirt H, Nemes C, Cavarretta I, Puhr M, Steiner H, Minelli A, Bartsch G, Offner F, Hobisch A, Doppler W, Culig Z
Suppressor of cytokine signaling-3 antagonizes cAMP effects on proliferation and apoptosis and is expressed in human prostate cancer.
Am J Pathol. 2006 Dec;169(6):2199-208.