Parajuli Nirmala, PhD

University / Clinic: Innsbruck Medical University
Institute: Biocenter, Division of Medical Biochemistry
Research Area:


Research Topic:
Establishment of a novel technique to produce precision cut slices of mammary tumors for short term cultures. Identification of tumor infiltrating myeloid cells as a main source of iNOS to mediate IFN gamma induced tumor killing via NO in slice cultures of MMTV-neu mice

Current position: University of Arkansas for Medical Sciences, Department of Pharamacology and Toxicology, Little Rock, AR 72205

Selected publications:
  Datta S, Parajuli N, Tymoszuk P, Ottina E, Parson W, Sgonc R, Villunger A, Doppler W
Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1.
J Leukoc Biol. 2014 Jun;95(6):853-66.

  Hannesdóttir L, Tymoszuk P, Parajuli N, Wasmer M, Philipp S, Daschil N, Datta S, Koller J, Tripp C, Stoitzner P, Müller-Holzner E, Wiegers G, Sexl V, Villunger A, Doppler W
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response
Eur J Immunol. 2013 Jun 12

  Parajuli N, Müller-Holzner E, Bock G, Werner E, Villunger A, Doppler W
Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice
Int J Cancer. 2010 Feb 15;126(4):896-908

  Parajuli N, Doppler W
Precision cut slice cultures of tumors from MMTV-neu mice for the study of the ex-vivo response to cytokines and cytotoxic drugs.
In Vitro Cell Dev Biol Anim. 2009 Sep;45(8):442-50. Epub 2009 Jun 16

  Haffner M, Jurgeit A, Berlato C, Geley S, Parajuli N, Yoshimura A, Doppler W
Interaction and functional interference of glucocorticoid receptor and SOCS1.
J Biol Chem, 283(32):22089-22096