Carlet Michela, PhD

University / Clinic: Innsbruck Medical University
Institute: Department of Molecular Pathophysiology
Research Area: GC-induced leukemia apoptosis


Career followup:
  UniKlinik Padua, Oncoematology Department

Research Topic:
Glucocorticoids inhibit proliferation and induce apoptosis in certain lymphocytes and lymphocyte-related malignancies leading to their therapeutic use in malignant lymphoproliferative disorders, most notably childhood acute lymphoblastic leukemia (ALL). The responsible molecular mechanisms of GC action remain, however, elusive. Our comparative gene expression profiling study using children with ALL during initial systemic GC monotherapy and related experimental systems identified PFKFB2 and SIK1 as possible candidates. The candidate genes were functional analysed to investigate their role in GC-induced apoptosis in ALL. зеленый кофе с имбирем

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Graduation: July 2010

Selected publications:
  Mansha M, Carlet M, Ploner C, Gruber G, Wasim M, Wiegers G, Rainer J, Geley S, Kofler R
Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia.
Leuk Res. 2010 Apr;34(4):529-34. Epub 2009 Jul 29.

  Wasim M, Carlet M, Mansha M, Greil R, Ploner C, Trockenbacher A, Rainer J, Kofler, R
PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis.
J Steroid Biochem Mol Biol. 2010 Jun;120(4-5):218-27. Epub 2010 May 6.

  Carlet M, Janjetovic K, Rainer J, Schmidt S, Panzer-Grümayer R, Mann G, Prelog M, Meister B, Ploner C, Kofler R
Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells.
BMC Cancer. 2010 Nov 23;10:638.

  Gruber G, Carlet M, Turtscher E, Meister B, Irving J, Ploner C, Kofler R
Levels of glucocorticoid receptor and its ligand determine sensitivity and kinetics of glucocorticoid-induced leukemia apoptosis.
Leukemia 23:820-823.