Schredelseker Johann, PhD

University / Clinic: Innsbruck Medical University
Institute: Department of Medical Genetics, Molecular and Clinical Pharmacology
Research Area: Skeletal-muscle excitation-contraction (EC) coupling


Research Topic:
Thesis title: "Excitation-contraction (EC) coupling in wild-type and mutant zebrafish"

Molecular mechanisms of excitation-contraction coupling and function of the L-type Calcium channel CaV1.1 with special regard to the role of the beta1a subunit.
Establishing wild-type and mutant zebrafish as model systems for excitation-contraction coupling.

Selected publications:
  Dayal A, Schredelseker J, Franzini-Armstrong C, Grabner M
Skeletal muscle excitation-contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPR β1a subunit
Cell Calcium. 2010 Jun;47(6):500-6. Epub 2010 May 6

  Schredelseker J, Shrivastav M, Dayal A, Grabner M
Non-Ca2+-conducting Ca2+ channels in fish skeletal muscle excitation-contraction coupling.
Proc Natl Acad Sci U S A. 107(12): 5658-63

  Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher B, Carsana A, Salvatore F, Grabner M
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavα1S-subunit.
Am J Physiol Cell Physiol 299(6):C1345-54

  Shrivastava M, Schredelseker J, Grabner M
Charged pore residues adjacent to the selectivity filter impede Ca2+ conductivity of the zebrafish DHPR α1S-b
Arch. Biochem. Biophys.; submitted

  Schredelseker J, Dayal A, Schwerte T, Franzini-Armstrong C, Grabner M.
Proper restoration of excitation-contraction coupling in the dihydropyridine receptor β1-null zebrafish relaxed is an exclusive function of the β1a subunit
J Biol Chem. 2009 Jan 9;284(2):1242-51. Epub 2008 Nov 13.

  Flucher B, Obermair GJ, Tuluc P, Schredelseker J, Kern G, Grabner M
The role of auxiliary dihydropyridine receptor subunits in muscle.
J Muscle Res Cell Motil. 2005;26(1):1-6. Epub 2005 Oct 14.

  Schredelseker J, Di Biase V, Obermair G, Felder E, Flucher B, Franzini-Armstrong C, Grabner M
The β1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle.
Proc Natl Acad Sci U S A, 102(47): 17219-24