Tuluc Petronel, PhD

University / Clinic: University of Innsbruck
Institute: Dept. of Pharmacology and Toxicology, Inst. of Pharmacy
Research Area: Calcium signaling in health and disease

Email: petronel.tuluc@i-med.ac.at

Research Topic:
Role of voltage gated calcium channels in hormone release
-Biophysical characterization of calcium channel voltage gating mechanism

Selected publications:
  Mastrolia V, Flucher S, Obermair G, Drach M, Hofer H, Renström E, Schwartz A, Striessnig J, Flucher B, Tuluc P
Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
Diabetes. 2017 Jan 23. pii: db151349. doi: 10.2337/db16-0336. [Epub ahead of print]

  Monteleone S, Lieb A, Pinggera A, Negro G, Fuchs JE, Hofer F, Striessnig J, Tuluc P, Liedl KR
Mechanisms Responsible for ω-Pore Currents in Cav Calcium Channel Voltage-Sensing Domains
Biophysical Journal 113, Nr. 7 (3. Oktober 2017): 1485–95

  Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J
Lower Affinity of Isradipine for L-Type Ca(2+) Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson’s Disease
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 37, Nr. 28 (12. Ju

  Tuluc P, Benedetti B, Costé de Bagneaux P, Grabner M, Flucher B
Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.
J Gen Physiol. 2016 Jun;147(6):437-49.

  Flucher B, Tuluc P
How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?
J Physiol. 2016 Nov 29. doi: 10.1113/JP273423. [Epub ahead of print]

  Benedetti B, Tuluc P, Mastrolia V, Dlaska C, Flucher B
Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1e.
Biophys J. 2015 Mar 10;108(5):1072-80.

  Pinggera A, Lieb A, Benedetti B, Lampert M, Monteleone S, Liedl K, Tuluc P, Striessnig J
CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels.
Biol Psychiatry. 2015 May 1;77(9):816-22.

  Striessnig J, Pinggera A, Kaur G, Bock G, Tuluc P
L-type Ca2+ channels in heart and brain.
Wiley Interdiscip Rev Membr Transp Signal. 2014 Mar 1;3(2):15-38.

  Ortner NJ, Bock G, Vandael DH, Mauersberger R, Draheim HJ, Gust R, Carbone E, Tuluc P, Striessnig J
Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.
Nature communications

  Campiglio M, Biase V, Tuluc P, Flucher B
Stable incorporation vs. dynamic exchange of β subunits in a native calcium channel complex.
J Cell Sci.126(Pt 9):2092-101. Epub 2013 Feb 27.

  Di Biase V, Tuluc P, Campiglio M, Obermair G, Heine M, Flucher B
Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons.
J Neurosci. 2011 Sep 21;31(38):13682-94

  Tuluc P, Flucher B
Divergent biophysical properties, gating mechanisms, and possible functions of the two skeletal muscle Ca(V)1.1 calcium channel splice variants.
J Muscle Res Cell Motil. 2011 Dec;32(4-5):249-56. Epub 2011 Nov 5.

  Flucher B, Tuluc P
A new L-type calcium channel isoform required for normal patterning of the developing neuromuscular junction.
Channels (Austin). 2011 Nov-Dec;5(6):518-24. Epub 2011 Nov 1.

  Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher B, Carsana A, Salvatore F, Grabner M
Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavα1S-subunit.
Am J Physiol Cell Physiol 299(6):C1345-54

  Tuluc P, Molenda N, Schlick B, Obermair G, Flucher B, Jurkat-Rott K
A CaV1.1 channel splice variant with high conductance and voltage-sensitivity alters EC-coupling in developing skeletal muscle
Biophys. J., 96:35-44.

  Obermair G, Tuluc P, Flucher B
Auxiliary Ca2+ channel subunits: Lessons learned from muscle
Curr. Opin. Pharmacol., March 6

  Tuluc P, Kern G, Obermair G, Kugler G, Flucher B
Depletion of the a2d-1 subunit from L-type Ca2+ channel alters cardiac action potential duration and myoplasmic Ca2+ transients.
Proc. Natl. Acad. Sci. USA, 104:11091-11096

  Obermair G, Kugler G, Baumgartner S, Tuluc P, Grabner M, Flucher, B
The Ca2+ channel a2d-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of a1S or excitation-contraction coupling.
J. Biol. Chem. 280:2229-2237

  Flucher B, Obermair GJ, Tuluc P, Schredelseker J, Kern G, Grabner M
The role of auxiliary dihydropyridine receptor subunits in muscle.
J Muscle Res Cell Motil. 2005;26(1):1-6. Epub 2005 Oct 14.

  Obermair G, Kugler G, Baumgartner S, Tuluc P, Grabner M, Flucher B
The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling.
J Biol Chem. 2005 Jan 21;280(3):2229-37. Epub 2004 Nov 9.