Lusser Alexandra, ao. Univ.-Prof. Dr. rer.nat.

University / Clinic: Medical University of Innsbruck
Institute: Division of Molecular Biology, Biocenter
Research Area: Chromatin and Epigenetics, Molecular Biology


Research Topic:
We study the mechanisms and biological functions of ATP-dependent chromatin remodeling factors. To this end, we use a combination of biochemical (e.g. fully purified recombinant assay systems) and genetic approaches (model organism Drosophila melanogaster ). We have characterized the SNF2-like ATPase CHD1 as a chromatin assembly factor with features distinct from the related motor protein ACF. We have also been studying the in vivo functions of CHD1 in the fly and we are interested in the processes that direct the assembly of specific histone variants, such as H3.3 and CENP-A, into the chromatin.

  Functional characterization of CENP-A interacting factors
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Selected publications:
  Boltengagen M, Huang A, Boltengagen A, Trixl L, Lindner H, Kremser L, Offterdinger M, Lusser A
A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
Nucleic Acids Res. 2016 Mar 18;44(5):2145-59.

  Sebald J, Willi M, Schoberleitner I, Krogsdam A, Orth-Höller D, Trajanoski Z, Lusser A
Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster
PLoS One. 2016 Apr 19;11(4):e0153476. doi: 10.1371/journal.pone.0153476. eCollection 2016.

  Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, Hechenberger C, Hackl H, Kessler R, Willi M, Gstir R, Krogsdam A, Lusser A, Poewe W, Wenning G, Hüttenhofer A, Stefanova N
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications
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  Etemad Ahari S, Obermair G, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher B
Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
J Neurosci. 2014 Jan 22;34(4):1446-61