Baier Gottfried, Univ.-Prof. Dr. rer.nat.
MCBO Co-Speaker

University / Clinic: Innsbruck Medical University
Institute: Department for Medical Genetics, Molecular and Clinical Pharmacology
 
Research Area: Experimental Cell Genetics

Email: gottfried.baier@i-med.ac.at
Web: baierlab.com


Research Topic:
The main function of mature T cells is to recognize and respond to foreign antigens by a complex activation process involving differentiation of the resting cell to a proliferating lymphoblast actively secreting immunoregulatory lymphokines or displaying targeted cytotoxicity, ultimately leading to recruitment of other cell types and initiation of an effective immune response. купить плед


In order to understand the physiology and pathophysiology of T lymphocytes, it is necessary to decode the biochemical processes that integrate signals from antigen, cytokine, integrin and death receptors. The principal upon which our work is based is to explore and identify gene products of distinct members of the AGC family of protein serine/threonine kinases as key players mediating cell growth regulation. купить плед киев


The underlying goal of the work is to understand their selective functions in signal transduction pathways in lymphocytes and to use this information to develop strategies to manipulate the immune response, either for immunosuppression in autoimmune diseases, graft rejection as well as the inflammatory response or for augmentation in cancer. To achieve these aims we apply modern biochemical, molecular, cellular and mouse genetic approaches.

The major research topic of the group of G. Baier relates to the biochemical, molecular and functional analysis of signal transducing AGC-protein S/T kinases within the haematopoietic system.

Project:
 
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Selected publications:
 
  Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J
Novel insights into the PKCβ-dependent regulation of the oxidoreductase p66Shc.
J Biol Chem. 2016 Sep 13. pii: jbc.M116.752766. [Epub ahead of print] PubMed PMID: 27624939.

  Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Sci Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930. PubMed PMID: 26868434; PubMed Central PMCID: P

  Pfeifhofer-Obermair C, Albrecht-Schgör K, Peer S, Nairz M, Siegmund K, Klepsch-Pedit V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Cell Commun Signal. 2016 Jul 28;14(1):14

  Siegmund K, Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.

  Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.
Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007. Epub 2016 Mar 15.

  Hermann-Kleiter N, Klepsch-Pedit V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep. 2015 Sep 29;12(12):2072-85.

  Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G
Protein Kinase C θ regulates Th17/Th1 plasticity in mouse CD4+ T lymphocytes.
PLoS One. 2014 May 2;9(5).

  Hermann-Kleiter N, Baier G
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.
Cell Commun Signal. 2014 Jun 12;12:38. doi: 10.1186/1478-811X-12-38.

  Lutz-Nicoladoni C, Thuille N, Wachowicz K, Gruber T, Leitges M, Baier G
PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription.
Immunology Letters. Epub 2013 Feb 21

  Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang C, Viola A, Pfeifhofer-Obermair C, Baier G
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.
J Mol Cell Biol. 2013 Jun 26

  Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R, Baier G
PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.
PLoS One. 2013;8(1): Epub 2013 Jan 15.

  Meisel M, Hermann-Kleiter N, Hinterleitner R, Gruber T, Wachowicz K, Pfeifhofer-Obermair C, Fresser F, Leitges M, Soldani C, Viola A, Kaminski S, Baier G
The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
Immunity. 2013 Jan 24;38(1):41-52; Epub 2013 Jan 3.

  Gruber T, Hinterleitner R, Pfeifhofer-Obermair C, Wolf D, Baier G
Engineering effective T-cell based antitumor immunity.
Oncoimmunology. 2013 Feb 1;2(2):e22893.

  Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A.
Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ. 2013 Apr;20(4):546-57

  Lutz-Nicoladoni C, Thuille N, Wachowicz K, Gruber T, Leitges M, Baier G
PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
Immunol Lett. 2014 Jul;160(1):104

  Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A.
Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.
Cell Death Differ. 2012 Dec 14

  Gruber T, Hinterleitner R, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger J, Loibner H, Lametschwandtner G, Wolf D, Baier G
Augmentation of tumor vaccine efficacy by combination with adoptive transfer of ex vivo synthetic siRNA cblb-silenced CD8+ T lymphocytes
PLOS ONE

  Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Müller M, Roth L, Katopodis A, Baier G
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.
J Autoimmun. 2012 Dec;39(4):428-40.

  Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger J, Loibner H, Lametschwandtner G, Wolf D, Baier G
Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model.
PLoS One. 2012;7(9):e44295.

  Paolino M, Thien C, Gruber T, Hinterleitner R, Baier G, Langdon W, Penninger J
Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b-Regulated T Cell Functions.
J Immunol. 2011 Feb 15;186(4):2138-47. Epub 2011 Jan 19

  Lutz-Nicoladoni C, Wallner S, Stoitzner P, Pircher M, Gruber T, Wolf A, Gastl G, Penninger J, Baier G, Wolf D
Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8(+) T cells combined with a DC vaccine.
Immunol Cell Biol. 2011

  Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger J, Baier G
Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.
J Autoimmun. 2011 Nov;37(3):198-208. Epub 2011 Jun 22.

  Hermann-Kleiter N, Baier G
NFAT pulls the strings during CD4+ T helper cell effector functions
Blood;115(15):2989-97.

  Hermann-Kleiter N, Baier G
NFAT pulls the strings during CD4+ T helper cell effector functions.
Blood. 2010 Apr 15;115(15):2989-97.

  Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
Mol Immunol. 2009 Jun;46(10):2071-9. Epub 2009 Apr 7

  Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger J, Baier G
PKC-theta Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation.
Science Signal. 2009 Jun 23;2(76):ra30

  Baier G, Wagner J
PKC inhibitors: potential in T cell-dependent immune diseases
Curr Opin Cell Biol. 2009 Apr;21(2):262-7.

  Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G
PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
Mol Immunol. 2009 Jun;46(10):2071-9.

  Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G.
The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity
Immunity

  Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber LA, Villunger A, Eichele G, Kaminski S, Baier G
The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity.
Immunity. 2008 Aug;29(2):205-16

  Letschka T, Kollmann V, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Obermair G, Fresser F, Leitges M, Hermann-Kleiter N, Kaminski S, Baier G
PKCtheta selectively controls the adhesion-stimulating molecule Rap1.
Blood. 2008 Dec 1;112(12):4617-27. Epub 2008 Sep 16

  Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G
The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity.

Immunity. 2008 Aug;29(2):205-16

  Kiessling S, Lutz C, Olsson A, Niederegger H, Baier G, Villunger A
Compensatory mechanisms regulate the Bcl-2 rheostat and lymphocyte survival in the absence of Akt1/PKB?
Cell Death Differ. 2007 Jan;14(1):186-9

  Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G
PKCθ and PKA are antagonistic partners in NF-AT activation of CD3+ T lymphocytes.
Blood. 15 June 2006 Jun 15;107(12):4841-8.

  Thuille N, Gruber T, Böck G, Leitges M, Baier G
PKC beta is dispensable for TCR-signaling.
Mol Immunol. 2004 Jun;41(4):385-90.

  Baier G
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